Rectal and Liver Metachronous Cancers and Sorafenib-Induced Thyroid Dysfunction
نویسندگان
چکیده
Ancuta Augustina Gheorghisan Galateanu1,2, Mara Carsote2,3*, Dan Peretianu4, Cristina Iosif5,6, Dana Terzea2,5 and Catalina Poiana2,3 1Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2“C.I.Parhon” National Institute of Endocrinology, Bucharest, Romania 3Department of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 4SCM Povernei Medical Centre, Bucharest, Romania 5OncoTeam Monza Hospital, Bucharest, Romania 6“Sfanta Maria” Hospital, Bucharest, Romania
منابع مشابه
Sorafenib induced thyroiditis in two patients with hepatocellular carcinoma.
BACKGROUND Sorafenib is a multi-targeted tyrosine kinase inhibitor licensed for the treatment of hepatocellular carcinoma and renal cell carcinoma. Thyroid function test abnormalities have been reported for different tyrosine kinase inhibitors, but only limited data on thyroid function test abnormalities related to sorafenib are available, demonstrating the occurrence of hypothyroidism in patie...
متن کاملCumulative incidence of metachronous colorectal cancer.
The incidence of metachronous colorectal cancer has most often been reported as a crude rate: second cancers/index cancers. The reported incidence varies between 0.5 percent and 3.6 percent. However, these calculations do not take into account factors such as length of survival and length of follow-up. The cumulative incidence more accurately reflects the risk for developing a metachronous canc...
متن کاملSorafenib-Induced Liver Failure: A Case Report and Review of the Literature
In patients with hepatocellular carcinoma characterized by vascular invasion and/or extrahepatic disease, Sorafenib is considered treatment of choice. Although mild liver test abnormalities were reported in less than 1% of the patients in the two large randomized, controlled phase III trials, four cases of severe acute Sorafenib-induced hepatitis have been described. One of these four cases die...
متن کاملEffect of Severe Hyperthyroidism on Concentrations of Nitric Oxide-producing Enzymes in Liver of Male Rats
Introduction: Thyroid hormones play an important role in normal function of liver and hyperthyroidism can cause liver dysfunction. Thyroid hormones affect nitric oxide (NO)-producing enzymes in liver. The aim of this study is to investigate effects of hyperthyroidism on protein levels of three isoforms of NO synthase (NOS) enzymes, including endothelial NOS (eNOS), inducible NOS (iNOS), and neu...
متن کاملSuccessful treatment for sorafenib-induced liver dysfunction: a report of case with liver biopsy.
Sorafenib is an oral multikinase inhibitor with anti-proliferative and anti-angiogenic effects and is used worldwide for the treatment of advanced or metastatic hepatocellular carcinoma (HCC). While the significant survival benefit of sorafenib in patients with advanced HCC was demonstrated, various treatment-related adverse events might happen. Of them, the incidence of drug-related severe liv...
متن کامل